A padrão of continuous (daily or almost daily) uso of opioids that has caused damage to a person’s physical or mental health or has resulted in behaviour leading to harm to the health of others. The padrão of continuous opioid uso is evident over a period of at least one month. Harm to health of the individual occurs due to one or more of the following: (1) behaviour related to intoxicação; (2) direct or secondary toxic effects on body organs and systems; or (3) a nocivo route of administration. Harm to health of others includes any form of physical harm, including trauma, or mental transtorno that is directly attributable to behaviour related to opioid intoxicação on the part of the person to whom the diagnosis of nocivo padrão of uso of opioids applies.