A padrão of uso of synthetic cannabinoids that has caused damage to a person’s physical or mental health or has resulted in behaviour leading to harm to the health of others. The padrão of synthetic cannabinoid uso is evident over a period of at least 12 months if substance uso is episodic or at least one month if uso is continuous (i.e., daily or almost daily). Harm to health of the individual occurs due to one or more of the following: (1) behaviour related to intoxicação; (2) direct or secondary toxic effects on body organs and systems; or (3) a nocivo route of administration. Harm to health of others includes any form of physical harm, including trauma, or mental transtorno that is directly attributable to behaviour related to synthetic cannabinoid intoxicação on the part of the person to whom the diagnosis of nocivo padrão of uso of synthetic cannabinoids applies.