Multiple specified psychoactive substance abstinência is a clinically significant cluster of symptoms, behaviours and physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of uso of multiple specified substances in individuals who have developed dependência or have used the specified substances for a prolonged period or in large amounts. Multiple specified psychoactive substance abstinência can also occur when prescribed psychoactive medications have been used in standard therapeutic doses. The specific features of the abstinência state depend on the pharmacological properties of the specified substances and their interactions.