An episódio of uso of MDMA or related drugs, including MDA, that has caused damage to a person’s physical or mental health or has resulted in behaviour leading to harm to the health of others. Harm to health of the individual occurs due to one or more of the following: (1) behaviour related to intoxicação; (2) direct or secondary toxic effects on body organs and systems; or (3) a nocivo route of administration. Harm to health of others includes any form of physical harm, including trauma, or mental transtorno that is directly attributable to behaviour due to intoxicação com MDMA or related drugs, including MDA, on the part of the person to whom the diagnosis of single episódio of nocivo uso applies. This diagnosis should not be made if the harm is attributed to a known padrão of uso of MDMA or related drugs, including MDA.