Synthetic cannabinoid abstinência is a clinically significant cluster of symptoms, behaviours and/or physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of uso of synthetic cannabinoids in individuals who have developed Synthetic cannabinoid dependência or have used synthetic cannabinoids for a prolonged period or in large amounts. Presenting features of Synthetic cannabinoid abstinência may include irritability, anger, aggression, shakiness, insomnia and disturbing dreams, restlessness, anxiety, depressed mood and appetite disturbance. In the early phase, Synthetic cannabinoid abstinência may be accompanied by residual features of intoxicação from the drug, such as paranoid ideation and auditory and visual hallucinations.